Human Recombinant p23 Protein -其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant p23 Protein

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-303B

规格：100 µg

目录价：￥4599

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant p23 Protein

别名:

Sid 3177 Protein, Co chaperone p23 Protein, cPGES Protein, HSP90 co chaperone Protein, cytosolic prostaglandin E2 synthase Protein, PTGES3 Protein, TEBP Protein

产品描述:

Human Recombinant p23 Protein

反应种属:

Human

实验应用:

WB | SDS-PAGE | Functional Assay

纯化方式:

Affinity Purified

偶联:

No tag

产品浓度:

Lot/batch specific. See included datasheet.

表达系统:

E. coli

保存温度:

-20ºC

运输温度:

Blue Ice or 4ºC

预期分子量:

~23 kDa

存储溶液:

20mM HEPES buffer pH7.2, 80mM NaCl, 10% glycerol

产地:

加拿大

功能与背景:

p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.

纯度:

>90%

Accession #:

NP_006592.3

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