Human Recombinant Superoxide Dismutase Protein Monomers-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Superoxide Dismutase Protein Monomers

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-435C

规格：100 µg x2

目录价：￥9702

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Superoxide Dismutase Protein Monomers

别名:

Superoxide dismutase1 Protein Monomer, ALS1 Protein Monomer, SOD1 Protein Monomer, IPOA Protein Monomer

产品描述:

Human Recombinant Superoxide Dismutase Protein Monomers

反应种属:

Human

实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

Lot/batch specific. See included datasheet.

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

15.936 kDa

存储溶液:

PB pH 7.4

产地:

加拿大

功能与背景:

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms (4). There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (7). SOD3 can also be distinguished by its heparin-binding capacity (1). Studies have shown that in vitro, Cu-Zn SOD (SOD1) fibrils are transduced into cells and function as seeds to trigger the aggregation of endogenously expressed SOD1 (9).

纯度:

>95%

Accession #:

NP_000445.1