Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-496B

规格：100 µg

目录价：￥6867

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)

别名:

MAPT, intracellular neurofibrillary tangles, NFTs, paired helical filaments, PHFs, 2N4R

产品描述:

Human Recombinant Tau-441 (2N4R) Wild-Type Monomers (Baculovirus/Sf9)

反应种属:

Human

实验应用:

WB | SDS PAGE | In vitro Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml

表达系统:

Baculovirus (Sf9)

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

45.84 kDa

存储溶液:

1X PB pH7.4

产地:

加拿大

功能与背景:

Brain-specific tau isoforms vary in the number of N-terminal inserts and C- terminal repeat domains due to alternative splicing of exons; the 2N4R isoform of tau is expressed in adult brain yet is absent from the fetal brain (1). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as Alzheimer’s Disease (AD) are characterized by neurofibrillary tangles containing hyper-phosphorylated tau fibrils (2). Hyper-phosphorylated tau can be generated via expression in the Sf9/Baculovirus system, with up to 20 sites confirmed by mass spectrometry and Western Blots with phospho-specific antibodies(3). Sf9/Baculovirus-expressed Tau 2N4R will readily form oligomers and fibrils in the absence of heparin.

纯度:

>95%