Human Recombinant Tau dGAE (AA297-391) Monomers-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Tau dGAE (AA297-391) Monomers

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-501XE

规格：500 µg (@5mg/ml)

目录价：￥18081

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Human Recombinant Tau dGAE (AA297-391) Monomers

别名:

Tau monomer, Tau protein monomer, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Monomer, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, Tau dGAE Protein, dGAE

产品描述:

Human Recombinant Tau dGAE (AA297-391) Monomers

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

Ion-exchange, ammonium sulfate precipitation and SEC purified

偶联:

No Tag

产品浓度:

2 mg/ml or 5 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

10.165 kDa

存储溶液:

10mM PB pH 7.4, 10mM DTT

产地:

加拿大

功能与背景:

Filamentous tau inclusions are a hallmark of many neurodegenerative diseases, including Alzheimer’s disease (AD) and Chronic Traumatic Encephalopathy (CTE), collectively called tauopathies. Advances in Cryo-EM have revealed that tau filaments isolated from individuals with a particular neurodegenerative disease share a distinct tau fold – i.e. an AD-isolated Tau filaments’ fold is distinct from a CTE-isolated Tau filaments’ fold (1-3). Utilizing Tau filaments with the correct disease-specific fold is an important goal towards better mimicking specific human diseases in cellular and in vivo models. Recent Cryo-EM studies have demonstrated that recombinantly generated Tau dGAE monomers will form the disease-isolated AD or CTE Tau filament folds under highly specific conditions in vitro (4, 5). StressMarq’s SPR-501 Tau (297-391) dGAE monomers are purified following these exact published procedures and can be utilized to form these distinct folds using specific aggregation conditions.

纯度:

>95%