Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils-其他重组蛋白-深圳欣博盛生物科技有限公司

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Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-461C

规格：100 µg x2

目录价：￥9954

产品详情

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产品名称:

Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils

别名:

Tau aggregate, Tau PFFs, Tau PFF, Tau protein aggregate, Tau protein, microtubule-associated protein Tau, MAPT, MAP, microtubule-associated protein, Truncated Tau Protein Aggregate, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 2, tubulin-associated unit, 95-amino acid Tau protein fragment, Truncated Tau Protein

产品描述:

Human Recombinant Truncated Tau Fragment (AA297-391) (dGAE) Protein Pre-formed Fibrils

反应种属:

Human

实验应用:

WB | SDS-PAGE | In vivo assay | In vitro assay

纯化方式:

Ion-exchange Purified

偶联:

No tag

产品浓度:

2 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

10.165 kDa

存储溶液:

10mM PB pH7.4, 10mM DTT

产地:

加拿大

功能与背景:

Alzheimer’s Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing paired helical filaments (PHFs). A truncated 95-amino acid fragment corresponding to residues 297-391 of full-length tau has been shown to assemble into PHF-like fibrils in vitro in the absence of additives or templates (3). This fragment has been found in the core of PHFs from AD brains and forms filaments that closely resemble PHFs isolated from AD brains (3).

纯度:

>95%

生物活性:

Thioflavin T emission curves show increased fluorescence (correlated to tau aggregation) over time when truncated tau fragment (AA297-391) (dGAE) monomer is combined with truncated tau fragment (AA297-391) (dGAE) Pre-formed Fibrils.

Accession #:

NP_005901.2