官网链接
折扣/货期| 货号：GTX74224 | 规格：100μg | 目录价：￥7200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
ICAD antibody
别名:
DFF1 , DFF45 , DFFA , DNA fragmentation factor subunit alpha , ICAD
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IP, WB
靶标/特异性:
This antibody recognizes non-cleaved (45kDa) and cleaved DFF.
同种型:
IgG
免疫原:
Peptide corresponding to aa 2-21 at the N-terminus of human DFF45 (accession no. NP_004392).
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
37
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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