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折扣/货期| 货号：GTX57185 | 规格：500μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IDH1 (R132H Mutant Specific) antibody [IHC132]
别名:
Isocitrate Dehydrogenase (Nadp(+)) 1, Cytosolic , Hel-216 , Hel-S-26 , Idcd , Idh , Idp , Idpc , Picd , Idh1
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
IgG1
免疫原:
Peptide against the C-Terminus of IDH1, with a point mutation at residual 132 where an Arginine R is changed to Histidine. protein.
克隆性:
Monoclonal
克隆号:
IHC132
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Tris, 1% BSA, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
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