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折扣/货期| 货号：92-695 | 规格：0.05 mg | 目录价：￥11969.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IDO Recombinant Protein
别名:
Indole 2, 3-dioxygenase, Indoleamine 2, 3-dioxygenase 1, IDO-1, IDO1, IDO, INDO
表达系统:
E. coli
保存温度:
Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
运输温度:
Dry Ice
产品形式:
Liquid
存储溶液:
Supplied as a 0.2 um filtered solution of 20mM Sodium Acetate, 150mM NaCl and 20% Glycerol, pH4.5. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
产地:
美国
生产商:
Prosci
功能与背景:
Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumor cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumor cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumor associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.
纯度:
Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/?g (1 IEU/?g) as determined by LAL test.
Endotoxin level less than 0.1 ng/?g (1 IEU/?g) as determined by LAL test.
Accession #:
P14902
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