官网链接
折扣/货期| 货号：40-318-0.005 mg | 规格：0.005 mg | 目录价：￥3783 |
| 货号：40-318-0.02 mg | 规格：0.02 mg | 目录价：￥5674.5 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IGF-BP4 Recombinant Protein
别名:
BP-4, IBP4, IGFBP-4, HT29-IGFBP, Insulin-like growth factor-binding protein 4, IBP-4
保存温度:
The lyophilized IGF-BP4 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted IGF-BP4 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing IGF-BP4 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
运输温度:
Blue Ice
产品形式:
Lyophilized
产地:
美国
生产商:
Prosci
功能与背景:
IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP4 is the major IGF-BP produced by osteoblasts, and is also found in the epidermis, ovarian follicles, and other tissues. IGF-BP4 inhibits the activity of IGF-I and IGF-II by binding in a manner that results in the formation of complexes with reduced ability to signal through cell surface IGF receptors. IGF-BP4 can inhibit the growth of chick pelvis cartilage and HT29 colon adenocarcinoma cells by blocking the mitogenic actions of IGFs, and has also been shown to reduce colony formation by colorectal cancer cells via an IGF independent pathway. The biological effects of IGF-BP4 can be regulated by Pregnancy Associated Plasma Protein A (PAPP-A), which reduces IGF-BP4/IGF binding affinity by proteolytically cleaving IGF-BP4. The modulation of IGF-BP4 activity by PAPP-A is an important component in the regulation of ovarian folliculogenesis and in the growth inhibition of responding ovarian cancer cells. Recombinant human IGF-BP4 is a 25.8 kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
纯度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
生物活性:
Biological activity was determined by its ability to inhibit IGF - I induced proliferation of FDC - P1 cells.
Accession #:
NP_001543.2
您可能感兴趣的产品
IL2 Recombinant Protein (e.coli Expressed)
货号：97-076
VEGF R2 Recombinant Protein
货号：97-070
EGF R Recombinant Protein
货号：97-063
EGF R Recombinant Protein
货号：97-062
M-CSF R Recombinant Protein
货号：97-015
M-CSF R Recombinant Protein
货号：97-014
IL-4 R alpha Recombinant Protein
货号：97-008
IL-4 R alpha Recombinant Protein
货号：97-007
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询