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折扣/货期| 货号：GTX88621 | 规格：100μg | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ikaros antibody, Internal
别名:
IKAROS family zinc finger 1 , CVID13 , Hs.54452 , IK1 , IKAROS , LYF1 , LyF-1 , PPP1R92 , PRO0758 , ZNFN1A1
反应种属:
Human
宿主来源:
Goat
实验应用:
WB
靶标/特异性:
This antibody is expected to recognise all reported human isoforms.
同种型:
IgG
免疫原:
Peptide with sequence C-DLLRAASENSQDALR, from the internal region of the protein sequence according to NP_006051.1; NP_001207694.1; NP_001207695.1; NP_001207696.1; NP_001207697.1; NP_001207698.1; NP_001207699.1; NP_001207700.1 and more.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
偶联:
Unconjugated
产品浓度:
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
58
产品形式:
Liquid
存储溶液:
TBS, 0.5% BSA, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]
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