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折扣/货期| 货号：CHI-HF-20001A-C010 | 规格：10 ug | 目录价：￥2940 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-1alpha (human) (rec.)
别名:
Interleukin-1alpha; IL-1F1; IL-1A
产品描述:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
宿主来源:
HEK 293 cells
保存温度:
+4°C
运输温度:
BI
预期分子量:
~19kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
生物活性:
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is < 0.001 ng/ml, corresponding to a specific activity of > 1 x 109units/mg.
内毒素水平:
<0.01EU/µg protein (LAL test; Lonza).
促销活动
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