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折扣/货期| 货号：AG-40B-0273-C050 | 规格：50 ug | 目录价：￥3600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IL-23R (human) (rec.) (His)
别名:
Interleukin-23 Receptor
产品描述:
IL-23 is a heterodimeric cytokine containing two subunits: p19 (encoded by IL23A) and p40 (encoded by IL12B). IL-23 signals via a heterodimeric receptor, IL-23R, composed of a specific subunit, IL23R, and the IL12Rbeta1 subunit, which is shared with the IL-12 receptor. IL-23R promotes mainly STAT3, but also STAT1, STAT4 and STAT5 phosphorylation. IL-23 supports the expansion and survival of established murine Th17 cells and enhances IFN-gamma production by memory CD4+ T cells. IL-23R is expressed on T cells, B cells, myeloid cells and NK cells. IL-23 signaling pathway is important in the pathogenesis of several chronic inflammatory diseases, including axial spondyloarthritis, axial spondyloarthritis, Crohn's disease and psoriasis. Cellular senescence is an age-associated mechanism that contributes to pathogenesis in diverse organ systems. In a recent study, it was observed that IL-23R, CCL5 and other proteins show age-dependent increases in circulation and are critical aging biomarkers, linked to senescence and are reduced by senotherapeutic agents. In human plasma, IL-23R abundance increases with age in both women and men. So, IL-23R seems to be a mediators of interorgan signaling mediated by senescent cells.
宿主来源:
HEK 293 cells. Produced using animal component-free medium.
靶标/特异性:
Binds to human and mouse IL-23.
产品浓度:
After reconstitution: 1mg/ml
保存温度:
+4°C
运输温度:
BI
预期分子量:
~60-65kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.02 EU/µg protein (LAL test).
促销活动
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