IL-33 Recombinant Protein-细胞因子、趋化因子与生长因子-深圳欣博盛生物科技有限公司

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IL-33 Recombinant Protein

品牌：ProSci LLC

官网链接

说明书

折扣/货期

货号：95-111

规格：0.05 mg

目录价：￥4226.625

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

IL-33 Recombinant Protein

别名:

IL-33 Antibody: DVS27, IL1F11, NF-HEV, NFEHEV, C9orf26, NFHEV, Interleukin-33, Interleukin-1 family member 11, IL-33

实验应用:

ELISA,WB

表达系统:

E. coli

保存温度:

Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

运输温度:

Dry Ice

产品形式:

Liquid

存储溶液:

100mM sodium phosphate, 500mM NaCl, 25 mM imidazole, 10% gycerol

产地:

美国

生产商:

Prosci

功能与背景:

Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1, IL-1Ra and IL-18 (1,2). Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling (1,3) and IL-1R accessory protein (IL-1RAcP) (4). Receptor binding of IL-33 activates NF-B and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine (2). Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties (5). This recombinant protein represents the cleaved and presumably activated form of IL-33, but has not been tested in any biological assays.

纯度:

~95%

Accession #:

NP_254274

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