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折扣/货期| 货号：GTX01494-08 | 规格：100test | 目录价：￥4100 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Integrin alpha 4 antibody [9F10] (PE)
别名:
integrin subunit alpha 4 , CD49D , IA4 , ITGA4 , Integrin alpha 4 , CD49d
产品描述:
The 9F10 monoclonal antibody reacts with human CD49d, a 150kD integral membrane protein that is also known as integrin αalpha4 (ITGA4). Together with integrin αbeta1 (CD29), CD49d forms the VLA-4 heterodimer that serves as a receptor for fibronectin and VCAM-1. VLA-4 is widely expressed on lymphocytes, monocytes, thymocytes, and NK cells. CD49d can also dimerize with integrin αbeta7 to form a receptor that binds the mucosal vascular addressin molecule, MAdCAM-1. CD49d is involved in cellular adhesion to other cells as well as extracellular matrix.
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM
同种型:
IgG1
克隆性:
Monoclonal
克隆号:
9F10
纯化方式:
Purified by affinity chromatography
偶联:
PE
产品浓度:
0.05 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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