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折扣/货期| 货号：GTX85258 | 规格：100μg | 目录价：￥6200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IRGC antibody
别名:
immunity related GTPase cinema , CINEMA , IFGGE , IRGC1 , Iigp5 , R30953_1
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, ICC/IF, WB
靶标/特异性:
Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.
同种型:
IgG
免疫原:
IRGC antibody was raised against a 12 amino acid synthetic peptide near the carboxy terminus of human IRGC.The immunogen is located within the last 50 amino acids of IRGC.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
50
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will recognize both isoforms.
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