官网链接
折扣/货期| 货号：AG-CR1-3672-M001 | 规格：1 mg | 目录价：￥720 |
| 货号：AG-CR1-3672-M005 | 规格：5 mg | 目录价：￥1920 |
| 货号：AG-CR1-3672-M025 | 规格：25 mg | 目录价：￥3960 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Oprozomib [ONX 0912]
别名:
O-Methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-L-serinamide; PR-047
产品描述:
Potent orally bioavailable irreversible proteasome inhibitor. Analog of Carfilzomib (Prod. No. AG-CR1-3669). Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=36nM) and the beta5i subunit [LMP7] of the 20S immunoproteasome (IC50=82nM). Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, as well as in bortezomib resistant multiple myeloma cells. Shown to have anti-angiogenic activity. Has potential applications in certain types of cancer as well as other diseases that require proteasome activity.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
532.6
产品形式:
solid
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
935888-69-0
分子式:
C25H32N4O7S
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