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折扣/货期| 货号：SIH-182-10MG | 规格：10 mg | 目录价：￥2073.6 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
J9
别名:
4-cyclopropyl-5-(pyridin-4-yl)pyrimidin-2-amine
产品描述:
Glucocorticoid resistance inhibitor
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
预期分子量:
212.26
产品形式:
White Solid
产地:
加拿大
功能与背景:
J9, in combination with dexamethasone inhibits cell growth in T-cell acute lymphoblastic leukemia (T-ALL) through the upregulation of the glucocorticoid receptor. Patients can develop glucocorticoid resistance rendering the treatment ineffective. J9 and its mechanism of action provides a useful strategy for overcoming the resistance. The EC50 of J9 in combination with dexamethasone is 28 uM. J9 alone was less toxic.
纯度:
99.9%
来源:
Synthetic
分子式:
C12H12N4
溶解度:
Soluble in CDCI3
PubChem CID:
PMC4094258
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