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折扣/货期| 货号：SIH-184-10MG | 规格：10 mg | 目录价：￥3384 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
VU0467154
别名:
5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide
产品描述:
M4 Receptor Agonist
保存温度:
-20ºC
运输温度:
Blue Ice or 4ºC
预期分子量:
444.45
产品形式:
Tan Solid
产地:
加拿大
功能与背景:
Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
纯度:
>98% (HPLC)
来源:
Synthetic
CAS号:
1451993-15-9
分子式:
C17H15F3N4O3S2
溶解度:
Soluble in DMSO
PubChem CID:
PMC4324418
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