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折扣/货期| 货号：GTX61742 | 规格：100μl | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
JNK (phospho Tyr185) antibody [EP1597Y]
别名:
Mitogen-Activated Protein Kinase 8 , Jnk , Jnk-46 , Jnk1 , Jnk1A2 , Jnk21B1/2 , Prkm8 , Sapk1 , Sapk1C , Mapk8
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
IP, WB
靶标/特异性:
This antibody is raised against JNK1/2 phosphorylated at Tyr185. Based on sequence homology, it is predicted to react with JNK3 when phosphorylated at the corresponding residues - Tyr223.
同种型:
IgG
免疫原:
A synthetic phospho-peptide corresponding to residues surrounding tyrosine 223 of human JNK3 was used as immunogen.
克隆性:
Monoclonal
克隆号:
EP1597Y
纯化方式:
Tissue culture supernatant
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
50mM Tris-Glycine, 150mM NaCl, 0.05% BSA, 40% Glycerol, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c . JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 . Unlike other JNK isoforms, JNK3 is only expressed in the heart and nervous system. JNK3 has been implicated in stress-induced neuronal apoptosis .
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