JNK1 antibody [1C2]-单抗-深圳欣博盛生物科技有限公司

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JNK1 antibody [1C2]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX84143

规格：100μl

目录价：￥7300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

JNK1 antibody [1C2]

别名:

mitogen-activated protein kinase 8 , JNK , JNK-46 , JNK1 , JNK1A2 , JNK21B1/2 , PRKM8 , SAPK1 , SAPK1c

反应种属:

Human, Mouse

宿主来源:

Mouse

实验应用:

ICC/IF, WB

同种型:

IgG2a

免疫原:

Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 (NP_002741) produced in E.coli.

克隆性:

Monoclonal

克隆号:

1C2

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells (By similarity). Phosphorylates heat shock factor protein 4 (HSF4). JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

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