KCNQ5 antibody-多抗-深圳欣博盛生物科技有限公司

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KCNQ5 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79177

规格：200μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

KCNQ5 antibody

别名:

potassium voltage-gated channel subfamily Q member 5 , Kcnq5l

反应种属:

Human, Rat

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody is specific for KCNQ5 and does not detect KCNQ1, KCNQ2, KCNQ3 or KCNQ4.

同种型:

IgG

免疫原:

Synthetic peptide corresponding to residues C(880) K A G E S T D A L S L P H V K L K(897) of human KCNQ5 protein.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.1% BSA, 0.05% Sodium azide.

生产商:

GeneTex

功能与背景:

KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KNCQs (KCNQ1-5) found in the central nervous system. Studies have shown that KCNQ3 and KCNQ5 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy. Voltage-dependent potassium channels are key regulators of the resting membrane potential and modulate the excitability of electrically active cells. The channels are usually tetrameric and can interact with auxiliary subunits that enhance or modify currents mediated by the pore-forming subunits.

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