KIR2DL3 antibody [GL183]-单抗-深圳欣博盛生物科技有限公司

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KIR2DL3 antibody [GL183]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX75190

规格：100μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

KIR2DL3 antibody [GL183]

别名:

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3 , CD158B2 , CD158b , GL183 , KIR-023GB , KIR-K7b , KIR-K7c , KIR2DL , KIR2DS5 , KIRCL23 , NKAT , NKAT2 , NKAT2A , NKAT2B , p58

反应种属:

Human

宿主来源:

Mouse

实验应用:

FCM, IP

靶标/特异性:

This antibody also recognises a 50kDa molecule in some NK clones, which is highly homologous to p58.2 in the extracellular domain, but has a shorter cytoplasmic tail (Moretta et al. 1985).

同种型:

IgG1

免疫原:

NK cell clone E57 (Moretta et al. 1985).

克隆性:

Monoclonal

克隆号:

GL183

纯化方式:

Purified IgG

偶联:

Unconjugated

产品浓度:

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.5% BSA, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

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