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折扣/货期| 货号：GTX80039 | 规格：100test | 目录价：￥4400 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
KIR2DL4 antibody [mAb#33] (PE)
别名:
CD158D , G9P , KIR , KIR103 , KIR103AS , KIR2DL4 , killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM
同种型:
IgG1
免疫原:
NK3.3 cells and KIR2DL4-Ig fusion protein
克隆性:
Monoclonal
克隆号:
mAb#33
纯化方式:
Purified by size-exclusion chromatography
偶联:
PE
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 15mM Sodium azide.
生产商:
GeneTex
功能与背景:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]
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