KIR3DS1 antibody, C-term-多抗-深圳欣博盛生物科技有限公司

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KIR3DS1 antibody, C-term

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX81103

规格：400μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

KIR3DS1 antibody, C-term

别名:

killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1 , CD158E2 , KIR-123FM , KIR-G1 , NKAT-10 , NKAT10

反应种属:

Human

宿主来源:

Rabbit

实验应用:

FCM, WB

同种型:

IgG

免疫原:

KLH conjugated synthetic peptide between 361-387 amino acids from the C-terminal region of human KIR3DS1.

克隆性:

Polyclonal

克隆号:

纯化方式:

Protein A purified, followed by peptide affinity purification.

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

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