KRT14 Antibody / Cytokeratin 14 / CK14-单抗-深圳欣博盛生物科技有限公司

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KRT14 Antibody / Cytokeratin 14 / CK14

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V4032-100UG	规格：100 ug	目录价：￥6414.1
货号：V4032-20UG	规格：20 ug	目录价：￥2963.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

KRT14 Antibody / Cytokeratin 14 / CK14

产品描述:

Cytokeratin 14 is a member of the type I keratin family of intermediate filament proteins. It always pairs with the type II keratin K5 and form the primary keratin pair of the keratinocytes of stratified squamous epithelia, including the epidermis as well as mucosal non-keratinizing stratified squamous epithelia. Cytokeratin 14 is strongly expressed in the undifferentiated basal cell layer containing the stem cells and are down-regulated in the differentiating suprabasal cell layers. Otherwise, in the widely well stratified follicular outer root sheath, cytokeratin 14 is uniformly expressed throughout all layers. The expression spectrum of cytokeratin 14 in tumors corresponds well to the patterns in normal epithelia. Thus, most squamous cell carcinomas as well as malignant mesotheliomas strongly express this keratin whereas little, focal, or no expression is found in adenocarcinomas. Cytokeratin 14 may be a useful marker in the differential diagnosis of squamous cell carcinoma from other epithelial tumors. Recent studies also indicate that CK14 expression in breast cancer corresponded with poor clinical outcome and that CK14 may have diagnostic value in the sub-classification of NSCLC.

反应种属:

Human

宿主来源:

Mouse

实验应用:

WB, IHC-P

同种型:

Mouse IgG2b, kappa

免疫原:

A portion of amino acids 350-472 was used as the immunogen for the KRT14 antibody.

克隆性:

Monoclonal (mouse origin)