Laminin 511 antibody [12D]-单抗-深圳欣博盛生物科技有限公司

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Laminin 511 antibody [12D]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX17688

规格：100μl

目录价：￥5800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Laminin 511 antibody [12D]

产品描述:

Laminins, which consist of three subunits called alpha, beta and gamma chains, are major cell-adhesive components of extracellular matrix, especially basement membranes (BMs). The laminin family is constituted of over 15 isoforms, and each member is expressed in a tissue-specific manner and plays a differential role in each tissue. Laminin-511 (Lm511) (formerly laminin-10), which consists of alpha 5, beta 1 and gamma 1 chains, appears at an early stage of development and is most widely expressed in adult tissues, mainly basement membranes of various epithelial tissues and vasculatures. Recently, laminin-511 is often used as a culture substrate for ES and iPS cells.This antibody specifically interacts with the trimeric structure of laminin-511 isoform but does not react with any of the alpha 5, beta 1 and gamma 1 chains in the reducing conditions. Furthermore, it has been validated that clone 12D does not react with any of laminins-111, -211, -332, -3B32, -411 and -521. Unlike conventional anti- alpha 5 antibodies, clone 12D distinguishes laminin-511 from laminin-521. This is an important tool to evaluate specific distribution and physiological functions of laminin-511. In human cancers, clone 12D detects small vascular vessels with high sensitivity and hence useful for evaluating tumor angiogenesis.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, IHC-Fr, IP, Purification, WB

靶标/特异性:

This antibody specifically interacts with the trimeric structure of laminin-511 isoform but does not react with any of the alpha 5, beta 1 and gamma 1 chains in the reducing conditions. Furthermore, it has been validated that clone 12D does not react with any of laminins-111, -211, -332, -3B32, -411 and -521. Unlike conventional anti- alpha 5 antibodies, clone 12D distinguishes laminin-511 from laminin-521.

同种型:

IgG2b

免疫原:

Human placental laminin.

克隆性:

Monoclonal

克隆号:

12D

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

Ascites, no preservatives.

生产商:

GeneTex

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