Laminin alpha 3B antibody [F7]-单抗-深圳欣博盛生物科技有限公司

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Laminin alpha 3B antibody [F7]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX17684

规格：100μl

目录价：￥6800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Laminin alpha 3B antibody [F7]

产品描述:

Laminins, which consist of three subunits called alpha, beta and gamma chains, are major cell-adhesive components of extracellular matrix, especially basement membranes (BMs). The laminin family is constituted of over 15 isoforms, and each member is expressed in a tissue-specific manner and plays a differential role in each tissue. In the case of laminin alpha 3 chain, there are two splicing variants, the truncated form alpha 3A and the full-length alpha 3B. Laminin-3B32 (Lm3B32) (formerly, laminin-5B) is composed of alpha 3B, beta 3 and gamma 2 chains and less widely expressed than laminin-3A32. Although laminin-3B32 shows higher cell adhesion activity than laminin-3A32 in vitro, differences of biological functions between two laminins remain to be clarified. Recent studies identified laminin-3B11 (Lm3B11) as a new alpha 3B-type laminin. Laminin-3B11 is localized in vascular basement membranes in normal tissues, but this expression is down-regulated in cancer tissues.Laminin-3B11 stimulates microvascular endothelial cells to extend lamelliopodial protrusions. This antibody (clone F7) detects laiminin-3B32 in the basement membranes of normal epithelial tissues and of relatively benign or differentiated carcinomas and laminin-3B11 in normal vascular basement membranes. This antibody is a powerful tool to detect laminin alpha 3B isoform and investigate its fundamental functions in epithelial and vascular basement membranes.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, IHC-Fr, IHC-P, IP, Purification, WB

靶标/特异性:

This antibody is specific for alpha 3B chain

同种型:

IgG1

免疫原:

Recombinant human laminin-alpha 3B N-term ~190 kDa fragment

克隆性:

Monoclonal

克隆号:

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

Ascites, no preservatives.

生产商:

GeneTex

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