官网链接
折扣/货期| 货号：GTX17686 | 规格：100μl | 目录价：￥6800 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Laminin gamma 2 antibody [P2H]
产品描述:
Laminins, which consist of three subunits called alpha, beta and gamma chains, are major cell-adhesive components of extracellular matrix, especially basement membranes (BMs). The laminin family is constituted of over 15 isoforms, and each member is expressed in a tissue-specific manner and plays a differential role in each tissue. Laminin gamma 2 chain is a subunit of laminin-332 isoform, formerly laminin-5, but it is frequently overexpressed as a monomer form or the beta3-gamma2 heterodimer in invasive cancers. Laminin gamma 2 is a protein of approximately 150 kDa and cleaved at its short arm mainly by bone morphogenic protein-1 (BMP1) in cancer cells, releasing an N-terminal proteolytic fragment (gamma 2pf) of 45 kDa. The short arm and gamma 2pf are also cleaved by MMPs and serine proteinases, releasing further small N-terminal fragments.This antibody recognizes laminin gamma 2 chain of laminin-332 on normal epithelial basement membranes, while in malignant cancer tissues it strongly immunostains the cytoplasm of cancer cells at invasion fronts. Thus, P2H is an important antibody capable of highly detecting the tumor invasion marker laminin gamma 2 chain. P2H is an only commercially available antibody to detect the N-terminal proteolytic fragments of laminin gamma 2 chain in cancer tissues. It is useful for pathological assessment of invasiveness and malignancy in various types of human cancers.
反应种属:
Human, Mouse
宿主来源:
Mouse
实验应用:
ELISA, IHC, IHC-P, WB
同种型:
IgG2a
免疫原:
Recombinant human gamma 2pf containing domain IV + V. Epitope: gamma 2 domain V, NE2.
免疫原种属:
Human
克隆性:
Monoclonal
克隆号:
P2H
纯化方式:
Unpurified
偶联:
Unconjugated
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Ascites, no preservative.
生产商:
GeneTex
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