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折扣/货期| 货号：GTX16897 | 规格：50μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LDL Receptor antibody [15C8]
别名:
Low Density Lipoprotein Receptor , Ldlr
反应种属:
Bovine, Human
宿主来源:
Mouse
实验应用:
ELISA, FCM, ICC/IF, IHC-Fr, IP, WB
同种型:
IgG2a
免疫原:
A trypic digest of low density lipoprotein receptor from bovine
克隆性:
Monoclonal
克隆号:
15C8
偶联:
Unconjugated
产品浓度:
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
50mM Sodium Phosphate, 0.2% Gelatin, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
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