Leptin Receptor antibody-多抗-深圳欣博盛生物科技有限公司

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Leptin Receptor antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX10979

规格：50μg

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Leptin Receptor antibody

别名:

leptin receptor , LEPROT , Leprb , Modb1 , OB-RGRP , Obr , db , diabetes , obese-like , obl

反应种属:

Mouse

宿主来源:

Goat

实验应用:

FCM, IHC-Fr, WB

同种型:

IgG

免疫原:

recombinant mouse leptin receptor expressed in NS0 cells.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 5% Trehalose, no preservatives.

生产商:

GeneTex

功能与背景:

Leptin is the adipocyte-specific product of the ob gene. Expression of leptin in fully fed animals reflects adipocyte size and body-fat mass. Leptin signals the status of body energy stores to the brain, where signals emanate to regulate food intake and whole-body energy expenditure. The leptin gene was identified in the leptindeficient, obese ob/ob mouse by positional cloning techniques. Recently, leptin has been cloned in domestic species including pigs, cattle, and chickens. The receptor for OB has been identified in mouse, human and rat. In mouse, the mature receptor is a 1142 aa residue, type I (extracellular N-terminal) transmembrane protein with a predicted molecular weight of 81 kDa. The molecule shows 817 aa residues in its extracellular segment, 21 aa residues in its transmembrane domain, and 302 aa residues in its cytoplasmic tail. Mouse, human and rat OB receptors are all virtually identical in length, with the mouse extracellular and cytoplasmic segments exhibiting 77% and 72% aa identity with their human counterparts. The OB receptor is described as being a gp130 analog. The leptin receptor has at least five splice variants; the long form of the receptor is primarily expressed in the hypothalamus and is thought to be the predominant signaling isoform. Leptin receptors are members of the cytokine family of receptors and signal via janus-activated kinases(JAK)/signal transducers and activators of transcription (STAT) and mitogen-activated protein kinase (MAPK) pathways. Mutations in the leptin or leptin receptor genes results in morbid obesity, infertility, and insulin resistance in rodents and humans. Leptin receptors are expressed in most tissues, and in vitro evidence suggests that leptin may have direct effects on some tissues such as adipose tissue, the adrenal cortex, and the pancreatic beta-cell. Leptin is thought to influence whole-body glucose homeostasis and insulin action.

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