LIMK1 antibody-多抗-深圳欣博盛生物科技有限公司

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LIMK1 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX02581

规格：100μg

目录价：￥6300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

LIMK1 antibody

别名:

LIM domain kinase 1 , LIMK , LIMK-1

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, IHC-P, IP, WB

同种型:

IgG

免疫原:

Synthetic peptide taken within amino acid region 550-647 on human LIM Kinase 1 protein.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

0.55 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

Tris/Glycine, 0.5% BSA, 30% Glycerol, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

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