anti-ER alpha (human), Rabbit Monoclonal (RM292)-单抗-深圳欣博盛生物科技有限公司

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anti-ER alpha (human), Rabbit Monoclonal (RM292)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：REV-31-1176-00-R100

规格：100 ul

目录价：￥5726

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

anti-ER alpha (human), Rabbit Monoclonal (RM292)

别名:

Estrogen Receptor

产品描述:

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 Estrogen receptor-alpha (ER-alpha) isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer and osteoporosis.

宿主来源:

Rabbit

实验应用:

IHC, WB

靶标/特异性:

This antibody reacts to reacts to human ER-alpha (Estrogen receptor).

同种型:

Rabbit IgG

免疫原:

A peptide corresponding to residues near the N-terminus of human ER-alpha.

克隆号:

RM292