Lipoyl-TRIM21 (human) (rec.) (His)-其他重组蛋白-深圳欣博盛生物科技有限公司

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Lipoyl-TRIM21 (human) (rec.) (His)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0182-3010	规格：3 x 10 ug	目录价：￥6720
货号：AG-40B-0182-C010	规格：10 ug	目录价：￥3360

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Lipoyl-TRIM21 (human) (rec.) (His)

别名:

E3 Ubiquitin-protein Ligase TRIM21; 52 kDa Ro Protein; Tripartite Motif-containing Protein 21

产品描述:

TRIM21 (tripartite motif-containing protein 21) is a cytosolic Fc receptor induced by interferon (IFN). TRIM21 is distinguished from other Fc receptors by showing broad antibody specificity as it can activate its functions upon binding to IgG, IgM as well as IgA while other Fc receptors display more restricted antibody isotype and subtype specificities. TRIM21 also functions as a E3 ligase. During infection, antibodies are delivered efficiently to the cytosol when bound to intracellular pathogens such as viruses and bacteria. The antibody-pathogen complex in the cytosol upon engagement of the protein TRIM21 is ubiquitinylated and degraded by the proteasome machinery. Trim-Away is a method to degrade endogenous proteins based on TRIM21, Fc receptor binding and ubiquitin ligase activity. TRIM21, which recognizes antibody-bound proteins of interest, targets them for degradation by the proteasome. The Lipoyl-TRIM21 (human) (His) (rec.) protein is used in the original papers describing Trim-Away.

宿主来源:

E. coli

产品浓度:

0.1mg/ml after reconstitution

保存温度:

+4°C

运输温度:

预期分子量:

~68kDa

产品形式:

solid

存储溶液: