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折扣/货期| 货号：GTX40384 | 规格：100μg | 目录价：￥4700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Low Density LRP antibody [8G1]
别名:
LDL receptor related protein 1 , A2MR , APOER , APR , CD91 , IGFBP-3R , IGFBP3R , IGFBP3R1 , KPA , LRP , LRP1A , TGFBR5
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM, IHC-Fr, IHC-P, WB
靶标/特异性:
Specifically reacts with the 515 kDa alpha-chain of human LRP/alpha2 MR expressed in certain cell types. A strongimmunohistochemical reaction is seen in hepatocytes, tissue macrophages, subsets of neurons and astrocytes in theCNS, fibroblasts, smooth muscle cells and monocyte-derived foam cells in atherosclerotic lesions of arterial walls.Will block a2M binding.
同种型:
IgG1
免疫原:
Human LRP/alpha2 MR
克隆性:
Monoclonal
克隆号:
8G1
纯化方式:
Protein A purified
偶联:
Unconjugated
产品浓度:
2.10 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
505
产品形式:
Liquid
存储溶液:
50mM Sodium Phosphate, 150mM NaCl, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
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