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折扣/货期| 货号：GTX04758 | 规格：100μl | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LRP2 antibody [ARC63830]
别名:
DBS,GP330,LDL receptor related protein 2,LRP2,Lrp2,Megalin
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
FCM, IHC-P, WB
同种型:
IgG
免疫原:
Recombinant fusion protein containing a sequence corresponding to amino acids 4446-4655 of human intracellular Megalin/LRP2 (NP_004516.2).
克隆性:
Monoclonal
克隆号:
ARC63830
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
522
产品形式:
Liquid
存储溶液:
PBS, 0.05% BSA, 50% glycerol, 0.05% proclin300.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009]
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