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折扣/货期| 货号：GTX54482 | 规格：50μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
mAChR M2 antibody [B8E5]
别名:
CHRM2,HM2,cholinergic receptor muscarinic 2,mAChR M2,Muscarinic Acetylcholine Receptor 2
反应种属:
Guinea pig, Human, Mouse, Rat
宿主来源:
Mouse
实验应用:
ELISA, Functional Assay, ICC/IF, IHC-Fr, WB
靶标/特异性:
Monoclonal antibody B8E5 acts by functional dimerization of the receptor resulting in stabilization of the constitutive active receptor dimers and paradoxically induces a small decrease in carbachol affinity for the M2 receptor. It recognizes the pentapeptide VRTVE (aa 168-172) corresponding to the N-terminal part of the second extracellular loop of the human M2 receptor.
同种型:
IgG2a
免疫原:
Peptide VRTVEDGECYIQFFSNAAVTFGTAI(C): Human second extracellular loop residues 168-192
克隆性:
Monoclonal
克隆号:
B8E5
纯化方式:
Purified IgG2a
偶联:
Unconjugated
产品浓度:
100 μg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Filter-sterilized PBS, 0.1% BSA, no preservatives.
生产商:
GeneTex
功能与背景:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
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