官网链接
折扣/货期| 货号：GTX110612 | 规格：100μl | 目录价：￥4000 |
| 货号：GTX110612-S | 规格：25μl | 目录价：￥1700 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MBD1 antibody [N2C2], Internal
别名:
methyl-CpG binding domain protein 1 , CXXC3 , PCM1 , RFT
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
免疫原:
Recombinant protein encompassing a sequence within the center region of human MBD1. The exact sequence is proprietary.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
67
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.
生产商:
GeneTex
功能与背景:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21. [provided by RefSeq]
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