MECP2 (phospho Ser80) antibody-多抗-深圳欣博盛生物科技有限公司

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MECP2 (phospho Ser80) antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX82658

规格：100μl

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MECP2 (phospho Ser80) antibody

别名:

methyl-CpG binding protein 2 , AUTSX3 , MRX16 , MRX79 , MRXS13 , MRXSL , PPMX , RS , RTS , RTT

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

IHC, WB

同种型:

IgG

免疫原:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser80 conjugated to KLH

克隆性:

Polyclonal

克隆号:

纯化方式:

Serum

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

10mM HEPES, 150mM NaCl, 0.01% BSA, 50% Glycerol, no preservatives.

生产商:

GeneTex

功能与背景:

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

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