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折扣/货期| 货号：V7663SAF-100UG | 规格：100 ug | 目录价：￥6652.1 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MerTK Antibody
产品描述:
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
Mouse IgG2a
免疫原:
A recombinant human partial protein (amino acids 55-148) was used as the immunogen for the MerTK antibody.
克隆性:
Monoclonal (mouse origin)
克隆号:
MERTK/3022
纯化方式:
Protein G affinity chromatography
保存温度:
Store the MerTK antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
产品形式:
Purified
存储溶液:
1 mg/ml in 1X PBS; BSA free, sodium azide free
产地:
美国
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