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折扣/货期| 货号：GTX52356 | 规格：100μg | 目录价：￥5300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MKP 1/2 antibody
别名:
dual specificity phosphatase 1 Antibody , HVH1 Antibody , MKP1 Antibody , MKP-1 Antibody , PTPN10 Antibody , CL100 Antibody , DUSP1 Antibody
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
DUS1
同种型:
IgG
免疫原:
A synthesized peptide derived from human MKP 1/2
克隆性:
Polyclonal
克隆号:
纯化方式:
Antigen affinity purification
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
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