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折扣/货期| 货号：GTX01906 | 规格：500μl | 目录价：￥11600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MLH1 antibody [ES05]
别名:
mutL homolog 1 , COCA2 , FCC2 , HNPCC , HNPCC2 , hMLH1
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
IgG1
免疫原:
Prokaryotic recombinant protein corresponding to 210 amino acids of human MLH1.
克隆性:
Monoclonal
克隆号:
ES05
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Tissue culture supernatant, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]
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