MMP24 antibody-多抗-深圳欣博盛生物科技有限公司

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MMP24 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX11649

规格：25μg

目录价：￥5000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MMP24 antibody

别名:

matrix metallopeptidase 24 , AU040325 , MMP-21 , MT5-MMP , MT5MMP , MTMMP5

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

ELISA, FCM, IHC-Fr, IP, WB

靶标/特异性:

Reacts with reduced and native MMP-24. Recognizes only the pro-form of MMP-24 and not the active forms.

同种型:

IgG

免疫原:

synthetic peptide corresponding to the propeptide region of mouse matrix metalloproteinase-24 (membrane-type matrix metalloproteinase-5).

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

~1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 50% Glycerol, 15mM Sodium azide.

生产商:

GeneTex

功能与背景:

Matrix Metalloproteinase 24 (MMP24, MT5MMP) has been described as a proteoglycanase, which is critical in the turnover of ECM (extracellular matrix) components in the brain. MMP24 contains a candidate signal sequence, a propeptide region, a potential furin recognition motif, a zinc-binding catalytic domain, a hemopexin-like domain, a 24-residue hydrophobic region, which acts as a potential transmembrane domain, and a short cytosolic domain. Unlike other MTMMPs, MMP24 (MT5MMP) sheds from the cell surface as soluble proteinases, allowing its versatility as both a cell bound and soluble proteinase in ECM remodeling processes. MMP24 is elevated in several tumor cell lines, and is also produced by some normal cell lines. It is predominantly expressed in the brain, indicating a role in nervous system development. MMP24 is also highly expressed during embryonic development. The mouse MMP24 gene maps to chromosome 2.

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