MOAT-B Antibody / Multi-specific organic anion transporter B / ABCC4-单抗-深圳欣博盛生物科技有限公司

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MOAT-B Antibody / Multi-specific organic anion transporter B / ABCC4

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V5644SAF-100UG

规格：100 ug

目录价：￥6652.1

产品详情

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产品名称:

MOAT-B Antibody / Multi-specific organic anion transporter B / ABCC4

产品描述:

The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the Mdr-1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter), and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 is highly expressed in liver and kidney, whereas MRP4 (also called MOAT-B) and MRP5 are detected in various tissues, yet at much lower levels of expression.

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P

同种型:

Mouse IgG2b, kappa

免疫原:

A portion of amino acids 1-200 from human ABCC4 protein was used as the immunogen for the MOAT-B antibody.

克隆性:

Monoclonal (mouse origin)