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折扣/货期| 货号：GTX84103 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MOB1B antibody [3G9]
别名:
MOB kinase activator 1B , MATS2 , MOB4A , MOBKL1A
反应种属:
Dog, Human, Monkey, Mouse, Rat
宿主来源:
Mouse
实验应用:
IHC-P, WB
同种型:
IgG2a
免疫原:
Full length human recombinant protein of human MOBKL1A(NP_775739) produced in HEK293T cell.
克隆性:
Monoclonal
克隆号:
3G9
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
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