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折扣/货期| 货号：GTX03684 | 规格：500μl | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Mucin 4 antibody [ZR201]
别名:
mucin 4, cell surface associated , ASGP , HSA276359 , MUC-4
产品描述:
Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of mucin 4results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of mucin 4 in pancreatic carcinoma by alltrans-retinoic acid is mediated through the retinoic acid receptor-å signaling pathway. MUC-4 is a very specific (100%) andsensitive (90%) marker of lung adenocarcinomas and is negative for mesotheliomas. MUC4 is expressed in many human adenocarcinomas. It is specifically expressed in lowgrade fibromyxoid sarcoma. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IHC-P
同种型:
IgG
免疫原:
Recombinant fragment (around aa 1730-1864) of human MUC4 prote
克隆性:
Monoclonal
克隆号:
ZR201
纯化方式:
Purified IgG
偶联:
Unconjugated
产品浓度:
batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
Tris-HCl, 0.2% BSA, 0.09% sodium azide.
生产商:
GeneTex
功能与背景:
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
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