MutL Homolog 1 Antibody / MLH1-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

MutL Homolog 1 Antibody / MLH1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V4038SAF-100UG

规格：100 ug

目录价：￥6414.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MutL Homolog 1 Antibody / MLH1

产品描述:

This MAb recognizes a protein of 83kDa, identified as MLH1. Defects in MLH1 are the cause of hereditary non-polyposis colorectal cancer type 2 (HNPCC2).Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process, which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma, which plays a role in meiosis.

反应种属:

Human

宿主来源:

Mouse

实验应用:

WB, IHC-P

同种型:

Mouse IgG1, kappa

免疫原:

Recombinant full-length human MLH1 protein was used as the immunogen for the MutL Homolog 1 antibody.

克隆性:

Recombinant Mouse Monoclonal