Myeloperoxidase antibody-多抗-深圳欣博盛生物科技有限公司

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Myeloperoxidase antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX22088

规格：100μl

目录价：￥4300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Myeloperoxidase antibody

别名:

myeloperoxidase

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ELISA, IP, WB

同种型:

IgG

免疫原:

Myeloperoxidase collected from human leukocytes

克隆性:

Polyclonal

克隆号:

偶联:

Unconjugated

产品浓度:

75 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

20mM Potassium Phosphate, 150mM NaCl, 0.01% Sodium azide.

生产商:

GeneTex

功能与背景:

Human myeloperoxidase (MPO) is a dimeric protein composed of two heavy subunits (53 kDa) and two light subunits (15 kDa). Each MPO molecule contains two prosthetic porphyrins which play an important role in the catalytic cycle. Molecular weights for MPO isoforms from pools of normal human samples range from 114,000 to 140,000 daltons reflecting a heterogeneous mixture of isoforms when assayed under non-reducing conditions of SDS-PAGE. Often MPO from a single donor will yield a homogenous preparation reflecting a single isoform. The carbohydrate component of MPO, consisting of mannose, glucose and N-acetylglucosamine residues is 2.5%. MPO is inhibited by azide and other compounds. MPO is stored in primary granules of neutrophils and serves as a bactericidal agent in that MPO catalyzes the production of hypochlorous acid (HOCl), a powerful oxidant. HOCl is derived from chloride ion (Cl-) and hydrogen peroxide (H2O2). In a number of inflammatory situations, MPO is released into the extracellular matrix where its measurement can be used as an indication of neutrophil activation.

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