MYH9 antibody-多抗-深圳欣博盛生物科技有限公司

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MYH9 antibody

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX11087

规格：100μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MYH9 antibody

别名:

myosin heavy chain 9 , BDPLT6 , DFNA17 , EPSTS , FTNS , MATINS , MHA , NMHC-II-A , NMMHC-IIA , NMMHCA

反应种属:

Dog, Human, Rat, Xenopus laevis

宿主来源:

Rabbit

实验应用:

ICC/IF, WB

同种型:

IgG

免疫原:

synthetic peptide corresponding to amino acids 1949-1960 of human nonmuscle myosin IIA.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by affinity chromatography

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

227

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 15mM Sodium azide.

生产商:

GeneTex

功能与背景:

Myosins belong to a superfamily of actin based motor proteins comprising to date at least 15 classes. There are two main groups of myosins: the conventional (class II) and the unconventional myosins. Myosin IIA (nonmuscle) is a relatively abundant, widespread two headed myosin composed of an N-terminal motor domain, a light chain binding neck region, a coiled-coil region, and a non helical C-terminal domain. It forms a heterohexamer composed of a pair of heavy chains and two pairs of light chains. The vertebrate myosin II class members include muscle (sarcomeric and smooth) and nonmuscle (cytoplasmic) myosins. The nonmuscle myosin II class contains two isoforms: IIA and IIB, which exhibit 85% and 72% amino acid identity in the motor domain and the rod, respectively. Varying ratios of the two isoforms are expressed in different cells and tissues. Some cells express only a single isotype: e.g. myosin IIA in human platelets, rat basophilic leukemia cells, and chicken intestinal epithelium and myosin IIB in embryonic cardiac myocytes and COS-7 cells. The two isoforms vary in their intracellular localization, enzymatic activities, and proposed functions. Three additional isoforms of IIB have been described in neurons. Another isoform, myosin IIC, seems to constitute a distinct third isoform of the nonmuscle myosins. Nonmuscle myosin II is involved in cell motility and adhesion, cytokinesis, vesicular transport, intracellular force generation, and in morphogenesis during development. Its activity is regulated by light chain and possibly heavy chain phosphorylation and by association with proteins such as Mts1. Mutations in the NMHCA gene are found in several syndromes associated with megakaryocyte/platelet/leukocyte disorders.

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