NCOA2 antibody [C2C3], C-term-多抗-深圳欣博盛生物科技有限公司

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NCOA2 antibody [C2C3], C-term

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX112307	规格：100μl	目录价：￥4000
货号：GTX112307-S	规格：25μl	目录价：￥1700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

NCOA2 antibody [C2C3], C-term

别名:

nuclear receptor coactivator 2 , GRIP1 , KAT13C , NCoA-2 , SRC2 , TIF2 , bHLHe75

反应种属:

Human

宿主来源:

Rabbit

实验应用:

ICC/IF, WB

同种型:

IgG

免疫原:

Recombinant protein encompassing a sequence within the C-terminus region of human NCOA2. The exact sequence is proprietary.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography.

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 1% BSA, 20% Glycerol, 0.01% Thimerosal.

生产商:

GeneTex

功能与背景:

The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM]

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