Neurogenin 3 Antibody / NGN3-单抗-深圳欣博盛生物科技有限公司

首页产品中心单抗

Neurogenin 3 Antibody / NGN3

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V9690-100UG	规格：100 ug	目录价：￥6414.1
货号：V9690-20UG	规格：20 ug	目录价：￥2963.1

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Neurogenin 3 Antibody / NGN3

产品描述:

This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, IF, FACS

同种型:

Mouse IgG2b

免疫原:

Recombinant human full-length protein was used as the immunogen for the Neurogenin 3 antibody.

克隆性:

Monoclonal (mouse origin)